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Projects underway

Brochure of all projects underway
　(both in Japanese and English)

Drugs

Classification Seeds Title Affiliation Name
Cancer Research aiming to develop refractory cancer therapeutics using protein-based drug delivery systems with drug release control function Graduate School of Agriculture, Osaka Metropolitan University Takashi INUI
Cancer Development of the new anti-cancer medicine targeting GREB1, a novel Wnt signal-related molecule 1. Center for Infectious Disease Education and Research, The University of Osaka
2. Graduate School of Biomedical Sciences, Tokushima University		 Akira KIKUCHI1,
Shinji MATSUMOTO2
Cancer Research and development of intellectual property for epigenomic drug discovery that dually targets cancer stem cells and cancer immunity Department of Medical Data Science, Graduate School of Medicine, The University of Osaka Hideshi ISHII
Cancer Maximizing cost-effectiveness by conjugating modifications for clinical application of innovative nucleic acid drugs Department of Medical Data Science, Graduate School of Medicine, The University of Osaka Hideshi ISHII
Cancer Antibody drug discovery against GPCR highly expressing in progressive and bone metastatic prostate cancer Proteo-Science Center, Ehime University Yuuki IMAI
Cancer Development of antibody-drug conjugates for the treatment of brain tumors Department of Pathology, Faculty of Medicine, Kindai University Akihiko ITO
Cancer Development of Dual-modified Biopharmaceuticals using N-terminal Protein Modification Faculty of Environmental Earth Science, Hokkaido University Akira ONODA
Cancer Development of anti-cancer drug with immunomodulators Initiative for Advanced Research, Gunma University Keisuke NIMURA
Cancer Development of anti-cancer drug targetting CKAP4 Center for Infectious Disease Education and Research, The University of Osaka Akira KIKUCHI
Cancer Development of innovative antibody therapy against ovarian cancer by controlling lipid metabolism
(Acquisition of non-clinical POC for novel antibody therapy using anti-LSR antibody for ovarian cancer)		 Division of Allergy and Rheumatology, Department of Internal Medicine,School of medicine Iwate Medical School  Tetsuji NAKA
Cancer Rapid clinical application of specific inhibitors targeting refractory gastrointestinal cancer stem cells Department of Medical Data Science, Graduate School of Medicine, The University of Osaka Hideshi ISHII
Cancer Development of Nucleic Acid Lipid Nanoparticles with Anticancer Effects Research Institute for Microbial Diseases, The University of Osaka／ Graduate School of Biomedical Sciences, Nagasaki University Taiki AOSHI
Cancer Innovative alpha therapy targeting PSMA for refractory prostate cancer Department of Radiology, Graduate School of Medicine, The University of Osaka Tadashi WATABE
Cancer Targeted alpha-ray therapy for refractory thyroid cancer Department of Radiology, Graduate School of Medicine, The University of Osaka Tadashi WATABE
Cancer Development of new oral cancer vaccine with the use of intestinal tract immunity Department of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe University Toshiro SHIRAKAWA
Cancer Development of a new treatment for chemotherapy-resistant triple-negative breast cancer Department of Advanced Molecular Therapy, Graduate School of Medicine, The University of Osaka Yoshiaki TANIYAMA
Cancer Development of magnetic nanoparticles for theranostics Yokohama National University Yuko ICHIYANAGI
Brain and Psychiatry Development of Improved Treatment Methods for Brain Function-Related Diseases (eating, metabolism, and mental health), Targeting the Vagal Afferent Nerves Graduate School of Life and Environmental Sciences, Kyoto Prefectural University Yusaku IWASAKI
Brain and Psychiatry Novel drug development for SSRI-resistant depression Department of Anatomy and Neuroscience Graduate School of Medicine, Osaka Metropolitan University Makoto KONDO
Brain and Psychiatry Development of a novel therapeutic drug for schizophrenia Graduate School of Biomedical and Health Sciences, Hiroshima University Yukio AGO
Brain and Psychiatry Development of ASOs for multiple system atrophy Department of Neurology, Graduate school of Medicine, The University of Osaka Yasuyoshi KIMURA,
Hideki MOCHIZUKI
Brain and Psychiatry Sensory medicine: Innovative therapeutics based on the principle of inducing the artificial hibernation / life-protective state by TRPA1 - activating odor molecules Kansai Medical University Ko KOBAYAKAWA
Infectious diseases Inhibition Aβ production by APP-targeting peptide Department of Medical Life Systems, Doshisha University Satoru FUNAMOTO
Infectious diseases Development of therapeutic strategy for mosquito-borne diseases by targeting mosquito saliva Department of Microbiology, Graduate School of Medicine, Juntendo University Tatsuya SUZUKI
Infectious diseases Development of a novel antibacterial that targets a molecular chaperone Faculty of Engineering, Tottori University Tomohiro MIZOBATA
Infectious diseases Development of a Novel Anti-African Trypanosomiasis Drug Targeting Cyanide-Resistant Respiration Gradate School of Medicine, Osaka Metropolitan University Yasutoshi KIDO
Infectious diseases Clinical Development of NPC-BKSE36/CpG Malaria Vaccine Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, The University of Osaka Toshihiro HORII
Cardiovascular diseases Novel therapeutic strategy for cerebral stroke using Npas4-related factors 1. Graduate school of medicine, The University of Osaka
2. Graduate school of pharmaceutical sciences, The University of Osaka		 Taiichi KATAYAMA1,
Akio TSUBOI2
Cardiovascular diseases Development of L862, an Innovative Pulmonary Hypertension Treatment Targeting TRPC3/6 Department of Cardiovascular Medicine Shinshu University School of Medicine Koichiro KUWAHARA
Cardiovascular diseases Development of novel companion PET diagnostics and therapeutic agents for myocarditis Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Osaka Ken MATSUOKA
Intractable diseases Development of new therapeutic agents focused on the liquidliquid phase separation phenomenon of cells Osaka Metropolitan University Hidemitsu NAKAJIMA
Intractable diseases Development of inhibitors of protein phosphatases involved in neurodegenerative diseases and investigation of their effects in animal models TThe department of Biological Control, RIMD, The University of Osaka Shizuka ISHITANI
Others Development of single-molecule imaging-based screening technology for drug discovery Graduate School of Frontier Biosciences, The University of Osaka Masahiro UEDA
Others Discovering Peptide-based Therapeutics for Neuropathic Pain Department of Biomedical Engineering Osaka Institute of Technology Emiko OKUDA-ASHITAKA
Others Development of repair therapy for skin barrier function by product lipids of novel lipase Department of Bio-system Pharmacology, Graduate School of medicine, The University of Osaka Ryuichi OHGAKI
Others Establishment of a new strategy for the treatment of functional restoration in skeletal muscle injury by tissue engineering using osteopontinederived SVVYGLR peptide Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, The University of Osaka Susumu TANAKA
Others A new anti-inflammatory drug that utilizes the active site of an endogenous NFkB direct inhibitory protein Department of Obstetrics & Gynecology, Graduate School of Medicine, The University of Osaka Kazuki OKAMOTO
Others Tissue targeting of lipid nanoparticles by N-terminal modification of peptides Faculty of Environmental Earth Science, Hokkaido University Mariko KOJIMA

Medical devices

Seeds Title Affiliation Name
Development of a new disinfection device using Pernitric acid solution Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, The University of Osaka Katsuhisa KITANO
Biodegradable polymer material design for new bioabsorbable stent using the materials maintain neutral after decomposition Nara Institute of Science and Technology Hiroharu AJIRO
Raman spectroscopic tissue detection for minimallyinvasive and precise medicine Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka Yasuaki KUMAMOTO
Construction of the rapid detection system of gut bacterium for health awareness improvement Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka Masato SAITO
Novel diagnostic marker to differentiate urogenital carcinoma by chiral amino acids in body fluids Department of Urology Graduate School of Medicine, The University of Osaka Atsunari KAWASHIMA
SPECT system for boron neutron capture therapy (BNCT-SPECT) for real-time measurement of therapeutic effect Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, The University of Osaka Isao MURATA
Development of highly efficient automatic bone marrow stem cell separate system for treatment of stroke patients Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe Akihiko TAGUCHI
Development of diagnostic and therapeutic methods for schizophrenia using eye movements National Center of Neurology and Psychiatry Ryota HASHIMOTO
Development of a novel scaffold suitable for the regeneration of injured nerve tissues Faculty of Biology-Oriented Science and Technology, Kindai University Koichi MORIMOTO
Development of “peptide” pulp capping agent promoting wound healing process of pulp tissue The University of Osaka Dental Hospital Yusuke TAKAHASHI
Development of a valved extracardiac conduit using in situ tissue restoration Osaka Medical and Pharmaceutical University, Department of Thoracic and Cardiovascular Surgery Shintaro NEMOTO
Restoration of Motor and Communication by Wireless Implantable Brain Machine Interfaces Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, The University of Osaka Masayuki HIRATA
Development of a robot arm for bone processing Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka Takahito FUJIMORI
Tumor diagnosis technology using AI analysis of the light spectrum of cytological specimens Medilux Research Center, Nara Institute of Science and Technology (NAIST) Yoichiroh HOSOKAWA

Regenerative medicine

Seeds Title Affiliation Name
Repair of incurable meniscal injuries using an aligned electrospun nanofibrous scaffold combined with mesenchymal stem cells Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka Kazunori SHIMOMURA
Regeneration therapy using autologous bone marrow derived M2 macrophage for severe heart failure The University of Osaka Hospital Kizuku YAMASHITA
Development of a novel therapy for α-synucleinopathy using regulatory T cells Department of Neurology, Graduate school of Medicine, The University of Osaka Yuto HAYASHI,
Hideki MOCHIZUKI
Study aiming to produce human iPSC-derived cell formulation for metabolic hepatic disorder Department of iPS Stem Cell Regenerative Medicine, Kansai Medical University Yasumasa SHIROUZU
Development of a novel treatment for pediatric craniofacial deformity using human reconstructed elastic cartilage Division of Regenerative Medicine, Institute of Medical Science, University of Tokyo Hideki TANIGUCHI
A Novel Therapeutic Vaccine against Multi-Drug Resistant Tuberculosis in the Clinical Trial (Investigator-initiated Clinical Trial (PhaseⅠ)) National Hospital Organization Kinki-Chuo Chest Medical Center Clinical Research Center Masaji OKADA
Development of novel treatment for malignant pleural mesothelioma using viral vector
(Investigator-initiated clinical trial of gene therapy using AdSOCS3 for malignant pleural mesothelioma)		 Division of Allergy and Rheumatology, Department of Internal Medicine, School of medicine Iwate Medical School Tetsuji NAKA
Development of oncolytic adenovirus agents composed of human adenovirus type 35 Graduate School of Pharmaceutical Sciences, The University of Osaka Hiroyuki MIZUGUCHI
Development of Liver Assist Device Using Hypoimmunogenic Hepatocyte System Graduate School of Medicine, The University of Osaka Takanori TAKEBE

Diagnostics

Seeds Title Affiliation Name
Development of a New Method for Detection of Effects Induced by Maternal Immune Activation Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka Shoichi SHIMADA
Rapid and“ in-situ” determination method of polyamines Kyoto Prefectural University, Graduate School of Life and Environmental Sciences Kazunori TSUBAKI
Development of pathological periostin measurement device Department of Advanced Molecular Therapy, Graduate School of Medicine, The University of Osaka Yoshiaki TANIYAMA
Development of a diagnostic method for patients with chronic inflammatory disease using analysis of sugar chains of IgGs Department of Biopathological Information Science, Graduate School of Medicine, The University of Osaka Eiji MIYOSHI
Prognosis biomarkers that can discriminate early-stage pancreatic cancer patients with worse prognosis prior to surgery Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University Keisuke TANIUCHI
Development of automatic rapid diagnosis for cervical lymph node metastasis of oral cancer Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine Koh-ichi NAKASHIRO