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Projects underway

Brochure of all projects underway
　(both in Japanese and English)

Drugs

Classification Seeds Title Affiliation Name
Cancer Research aiming to develop refractory cancer therapeutics using protein-based drug delivery systems with drug release control function Graduate School of Agriculture, Osaka Metropolitan University Takashi INUI
Cancer Photodynamic Therapy Reagents Targeting Mitochondria Using Polyamine Tethers Faculty of Environmental Earth Science, Hokkaido University Akira ONODA
Cancer Development of the new anti-cancer medicine targeting GREB1, a novel Wnt signal-related molecule 1. Center for Infectious Disease Education and Research, Osaka University
2. Department of Molecular Biology & Biochemistry, Graduate School of Medicine, Osaka University		 Akira KIKUCHI1,
Shinji MATSUMOTO2
Cancer Development of new therapeutic methods for hepatocellular carcinoma targeting molecules downstream of PKR Department of Gastroenterology and Metabology, Graduate School of Medicine, Ehime University Yoichi HIASA
Cancer Research and development of intellectual property for epigenomic drug discovery that dually targets cancer stem cells and cancer immunity Department of Medical Data Science, Graduate School of Medicine, Osaka University Hideshi ISHII
Cancer Maximizing cost-effectiveness by conjugating modifications for clinical application of innovative nucleic acid drugs Department of Medical Data Science, Graduate School of Medicine, Osaka University Hideshi ISHII
Cancer Antibody drug discovery against GPCR highly expressing in progressive and bone metastatic prostate cancer Proteo-Science Center, Ehime University Yuuki IMAI
Cancer Development of antibody-drug conjugates for the treatment of brain tumors Department of Pathology, Faculty of Medicine, Kindai University Akihiko ITO
Cancer Development of novel therapeutic agents for refractory BRAF mutation-positive colorectal cancer Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Hidekazu TAKAHASHI
Cancer Development of Dual-modified Biopharmaceuticals using N-terminal Protein Modification Faculty of Environmental Earth Science, Hokkaido University Akira ONODA
Cancer Development of anti-cancer drug with immunomodulators Initiative for Advanced Research, Gunma University Keisuke NIMURA
Cancer Development of anti-cancer drug targetting CKAP4 Center for Infectious Disease Education and Research, Osaka University Akira KIKUCHI
Cancer Development of innovative antibody therapy against ovarian cancer by controlling lipid metabolism
(Acquisition of non-clinical POC for novel antibody therapy using anti-LSR antibody for ovarian cancer)		 Division of Allergy and Rheumatology, Department of Internal Medicine,School of medicine Iwate Medical School  Tetsuji NAKA
Cancer Rapid clinical application of specific inhibitors targeting refractory gastrointestinal cancer stem cells Department of Medical Data Science, Graduate School of Medicine, Osaka University Hideshi ISHII
Cancer Development of Nucleic Acid Lipid Nanoparticles with Anticancer Effects Research Institute for Microbial Diseases, Osaka University／ Graduate School of Biomedical Sciences, Nagasaki University Taiki AOSHI
Cancer Innovative alpha therapy targeting PSMA for refractory prostate cancer Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University Tadashi WATABE
Cancer Targeted alpha-ray therapy for refractory thyroid cancer Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University Tadashi WATABE
Cancer Development of new oral cancer vaccine with the use of intestinal tract immunity Department of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe University Toshiro SHIRAKAWA
Cancer Development of a new treatment for chemotherapy-resistant triple-negative breast cancer Department of Advanced Molecular Therapy, Graduate School of Medicine, Osaka University Yoshiaki TANIYAMA
Brain and Psychiatry Development of Improved Treatment Methods for Brain Function-Related Diseases (eating, metabolism, and mental health), Targeting the Vagal Afferent Nerves Graduate School of Life and Environmental Sciences, Kyoto Prefectural University Yusaku IWASAKI
Brain and Psychiatry Development of therapeutic agents for amyotrophic lateral sclerosis by improving ribosome function Department of Neurotherapeutics, Graduate School of Medicine, Osaka University Seiichi NAGANO
Brain and Psychiatry Novel drug development for SSRI-resistant depression Department of Anatomy and Neuroscience Graduate School of Medicine, Osaka Metropolitan University Makoto KONDO
Brain and Psychiatry Development of a novel therapeutic drug for schizophrenia Graduate School of Biomedical and Health Sciences, Hiroshima University Yukio AGO
Brain and Psychiatry Development of ASOs for multiple system atrophy Department of Neurology, Graduate school of Medicine, Osaka University Yasuyoshi KIMURA,
Hideki MOCHIZUKI
Brain and Psychiatry Sensory medicine: Innovative therapeutics based on the principle of inducing the artificial hibernation / life-protective state by TRPA1 - activating odor molecules Kansai Medical University Ko KOBAYAKAWA
Infectious diseases Development of Reoviridae virus-based mucosal vaccine vector systems Research Institute for Microbial Diseases, Osaka University Takeshi KOBAYASHI
Infectious diseases Development of therapeutic strategy for mosquito-borne diseases by targeting mosquito saliva Department of Microbiology, Graduate School of Medicine, Juntendo University Tatsuya SUZUKI
Infectious diseases Development of a novel antibacterial that targets a molecular chaperone Tottori University Tomohiro MIZOBATA
Infectious diseases Molecular understanding of the nuclear transport mechanism of flavivirus components and drug discovery National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Yoichi MIYAMOTO
Infectious diseases Development of peptide-based universal CTL vaccine for SARS-CoV-2 Hyogo Medical University Satoshi ISHIDO
Infectious diseases Development of a Novel Anti-African Trypanosomiasis Drug Targeting Cyanide-Resistant Respiration Gradate School of Medicine, Osaka Metropolitan University Yasutoshi KIDO
Infectious diseases Clinical Development of NPC-BKSE36/CpG Malaria Vaccine Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University Toshihiro HORII
Cardiovascular diseases Novel therapeutic strategy for cerebral stroke using Npas4-related factors 1. Graduate school of medicine, Osaka University
2. Graduate school of pharmaceutical sciences, Osaka University		 Taiichi KATAYAMA1,
Akio TSUBOI2
Cardiovascular diseases Research for Development of Drug for abdominal aortic aneurysm Faculty of Agriculture, Kindai University Nobuhiro ZAIMA
Cardiovascular diseases Development of L862, an Innovative Pulmonary Hypertension Treatment Targeting TRPC3/6 Department of Cardiovascular Medicine Shinshu University School of Medicine Koichiro KUWAHARA
Cardiovascular diseases Development of First-in-class Drug for Bradyarrhythmia
(NTC-801F KACh Channel Inhibitor Phase II clinical trial)		 Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University Yoshihiro ASANO
Intractable diseases Development of new therapeutic agents focused on the liquidliquid phase separation phenomenon of cells Osaka Metropolitan University Hidemitsu NAKAJIMA
Intractable diseases New drug discovery for Fabry disease Center for Medical Research & Development, Osaka Medical and Pharmaceutical University Michio ASAHI
Intractable diseases Evaluation of KN3014 a candidate small compound for cryopyrin-associated periodic syndromes (CAPS) in a mouse model Division of Pathology, Proteo-Science Center, Ehime University Junya MASUMOTO
Intractable diseases Region-specific LOH-inducing applied to HLA region and the sensitive region extracted by GWAS Genome Editing Research and Development Center, Graduate School of Medicine, Osaka University Yasuhide YOSHIMURA
Intractable diseases Development of inhibitors of protein phosphatases involved in neurodegenerative diseases and investigation of their effects in animal models The department of Biological Control, RIMD, Osaka University Shizuka ISHITANI
Others Development of single-molecule imaging-based screening technology for drug discovery Graduate School of Frontier Biosciences, Osaka University Masahiro UEDA
Others Discovering Peptide-based Therapeutics for Neuropathic Pain Department of Biomedical Engineering Osaka Institute of Technology Emiko OKUDA-ASHITAKA
Others Development of repair therapy for skin barrier function by product lipids of novel lipase Department of Bio-system Pharmacology, Graduate School of medicine, Osaka University Ryuichi OHGAKI
Others Optimization and functional analysis of active form of IC-2 showing hepatic fibrosis inhibitory effect Division of Medical Genetics and Regenerative Medicine, Faculty of Medicine, Tottori University Noriko ITABA
Others Establishment of a new strategy for the treatment of functional restoration in skeletal muscle injury by tissue engineering using osteopontinederived SVVYGLR peptide Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University Susumu TANAKA
Others A new anti-inflammatory drug that utilizes the active site of an endogenous NFkB direct inhibitory protein Department of Obstetrics & Gynecology, Graduate School of Medicine, Osaka University Kazuki OKAMOTO
Others Development of prophylaxis of aspiration pneumonia by aural stimulation with capsaicin ointment Department of Otolaryngology, University of Tokushima School of Medicine Yoshiaki KITAMURA

Medical devices

Seeds Title Affiliation Name
AI Estimation of the Wall Fragility Site of Cerebral Aneurysm Based on 4D-CTA and 4D-MRA Medical Images and Clinical Application of Head Models Department of Pure and Applied Mathematics, Graduate School of Information Science and Technology, Osaka University Yoshie SUGIYAMA
Development of a new disinfection device using Pernitric acid solution Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University Katsuhisa KITANO
Diamond bur for suppressing heat generation in bone resection Graduate School of Engineering, Osaka University Urara SATAKE
Visualization Technology for Disease States Based on Multidimensional Chemical Distribution Information Department of Physics, Graduate School of Science, Osaka University Yoichi OTSUKA
Biodegradable polymer material design for new bioabsorbable stent using the materials maintain neutral after decomposition Nara Institute of Science and Technology Hiroharu AJIRO
Development of thin and soft cooling device to prevent secondary damages during convalescent phase after severe brain injury Kyoto Institute Technology, Faculty of Materials Science and Engineering Tohru SUGAHARA
Research for improving the medical environment using “Nanospikes” that physically exhibit antibacterial properties Kansai University Takeshi ITO
Raman spectroscopic tissue detection for minimallyinvasive and precise medicine Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University Yasuaki KUMAMOTO
Construction of the rapid detection system of gut bacterium for health awareness improvement Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University Masato SAITO
Development of New Techniques for Wireless EEG Measurement Device with Light Weight and Long Time Operation Division of Electrical, Electronic and Infocommunications Engineering Graduate School of Engineering, Osaka University Daisuke KANEMOTO
Quantitative diagnostic method of skin cancer based on the combination of melanoma discrimination by deep learning of clinical images and the information of blood flow images Kinjo Gakuin University Tsugunobu ANDOH
Practical application of plasma molecule introduction device for cell medicine and gene therapy Electrical Energy Conversion Engineering Laboratory Faculty of Engineering, Ehime University Masafumi JINNO
Development of continence device for ostomy Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University Kazutaka OBAMA
Novel diagnostic marker to differentiate urogenital carcinoma by chiral amino acids in body fluids Department of Urology Graduate School of Medicine, Osaka University Atsunari KAWASHIMA
SPECT system for boron neutron capture therapy (BNCT-SPECT) for real-time measurement of therapeutic effect Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University Isao MURATA
Potential Medical Devices for Osteoarthritis Department of Mechanical Engineering, Osaka Sangyo University Takehito HANANOUCHI
Software as a medical device SaMD for predicting and diagnosing fetal abnormalities in cardiotocography CTG Faculty of Medical Sciences, University of Fukui Yoshio YOSHIDA,  Chikahiro ARAKI
Development of highly efficient automatic bone marrow stem cell separate system for treatment of stroke patients Foundation for Biomedical Research and Innovation at Kobe Institute of Biomedical Research and Innovation Akihiko TAGUCHI
Development of multipurpose nerve conduits with higher flexibility for nerve regeneration using 3D transplantation of iPS cells, nerve capping and nerve wrapping Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine Kiyohito TAKAMATSU
Development of diagnostic and therapeutic methods for schizophrenia using eye movements National Center of Neurology and Psychiatry Ryota HASHIMOTO
Development of a novel scaffold suitable for the regeneration of injured nerve tissues Kindai University Koichi MORIMOTO
Development of an AI system to predict facial morphology after orthodontic treatment Department of Orthodontics, Osaka University Dental Hospital Chihiro TANIKAWA
Development of a medical device to visualize abnormalities in the 3D surface morphology of the skull as a color map Department of Orthodontics, Osaka University Dental Hospital Chihiro TANIKAWA
Development of “peptide” pulp capping agent promoting wound healing process of pulp tissue Osaka University Dental Hospital Yusuke TAKAHASHI
Development of a valved extracardiac conduit using in situ tissue restoration Osaka Medical and Pharmaceutical University, Department of Thoracic and Cardiovascular Surgery Shintaro NEMOTO
Development of minimally invasive device system  for evaluating the prospect of uterine receptivity for each cycle Department of Obstetrics & Gynecology, Graduate School of Medicine, Osaka University Tadashi KIMURA
Restoration of Motor and Communication by Wireless Implantable Brain Machine Interfaces Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University Masayuki HIRATA
Research and development of innovative remote cardiac rehabilitation system Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University Yasushi SAKATA,
Tatsunori TANIGUCHI

Regenerative medicine

Seeds Title Affiliation Name
Repair of incurable meniscal injuries using an aligned electrospun nanofibrous scaffold combined with mesenchymal stem cells Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka University Kazunori SHIMOMURA
Development of Meniscus Regeneration Therapy Using Human Umbilical Cord TissueDerived Mesenchymal Stem Cells and Atelocollagen Meniscus Regeneration Materia Department of Health and Sport Sciences, Medicine for Sports and Performing Arts, Graduate School of Medicine, Osaka University Ken NAKATA
Regeneration therapy using autologous bone marrow derived M2 macrophage for severe heart failure Osaka University Hospital Kizuku YAMASHITA
Development of a novel therapy for α-synucleinopathy using regulatory T cells Department of Neurology, Graduate school of Medicine, Osaka University Hideki MOCHIZUKI
Study aiming to produce human iPSC-derived cell formulation for metabolic hepatic disorder Department of iPS Stem Cell Regenerative Medicine, Kansai Medical University Yasumasa SHIROUZU
Improvement of hematopoietic stem cell function based on the mechanism of action to promote regeneration of damaged tissues Department of Regenerative medicine research Institute of Biomedical Research and Innovation Foundation for Biomedical Research and Innovation at Kobe Akihiko TAGUCHI
Development of a novel treatment for pediatric craniofacial deformity using human reconstructed elastic cartilage Division of Regenerative Medicine, Institute of Medical Science, University of Tokyo Hideki TANIGUCHI
Development of Umbilical Cord Blood Derived cellular Drug for Stroke Department of Regenerative Medicine Research Institute of Biomedical Research and Innovation at Kobe Yuko OGAWA
Establishment of a clinical application technique for breast reconstruction using in vitro vascularized 3D adipose tissue Department of Plastic Surgery, Jichi Medical University Yoshihiro SOWA
Development of new periodontal tissue regeneration therapy using autologous adipose tissue-derived stem cells Graduate School of Dentistry, Osaka University Shinya MURAKAMI,
Masahide TAKEDACHI
A Novel Therapeutic Vaccine against Multi-Drug Resistant Tuberculosis in the Clinical Trial (Investigator-initiated Clinical Trial (PhaseⅠ)) National Hospital Organization Kinki-Chuo Chest Medical Center Clinical Research Center Masaji OKADA
Development of novel treatment for malignant pleural mesothelioma using viral vector
(Investigator-initiated clinical trial of gene therapy using AdSOCS3 for malignant pleural mesothelioma)		 Division of Allergy and Rheumatology, Department of Internal Medicine, School of medicine Iwate Medical School Tetsuji NAKA

Diagnostics

Seeds Title Affiliation Name
Identification of unknown skin autoantigen of autoimmune bullous disease aiming for patent application and development of comprehensive aotoantibody measurement system Belongs Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, and AIBD LAB Co., Ltd. Takashi HASHIMOTO
Development of a New Method for Detection of Effects Induced by Maternal Immune Activation Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka Uiversity Shoichi SHIMADA
Establishment and clinical application of rapid and highly accurate identification method for nontuberculous mycobacteriosis by real-time core genome analysis Immunology Frontier Research Center, Osaka University Kiyoharu FUKUSHIMA
Rapid and“ in-situ” determination method of polyamines Kyoto Prefectural University, Graduate School of Life and Environmental Sciences Kazunori TSUBAKI
Development of pathological periostin measurement device Department of Advanced Molecular Therapy, Graduate School of Medicine, Osaka University Yoshiaki TANIYAMA
Development of a diagnostic method for patients with chronic inflammatory disease using analysis of sugar chains of IgGs Department of Biopathological Information Science, Graduate School of Medicine, Osaka University Eiji MIYOSHI
Prognosis biomarkers that can discriminate early-stage pancreatic cancer patients with worse prognosis prior to surgery Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University Keisuke TANIUCHI
Development of automatic rapid diagnosis for cervical lymph node metastasis of oral cancer Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine Koh-ichi NAKASHIRO